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Review Question - QID 213188

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QID 213188 (Type "213188" in App Search)
A 14-year-old boy is brought in to the clinic by his parents for weird behavior for the past 4 months. The father reports that since the passing of his son's pet rabbit about 5 months ago, his son has been counting during meals. It could take up to 2 hours for him to finish a meal as he would cut up all his food and arrange it in a certain way. After asking the parents to leave the room, you inquire about the reason for these behaviors. He believes that another family member is going to die a “terrible death” if he doesn’t eat his meals in multiples of 5. He understands that this is unreasonable but just can’t bring himself to stop. Which of the following abnormality is this patient's condition most likely associated with?

Atrophy of the frontotemporal lobes

0%

0/47

Atrophy of the hippocampus

2%

1/47

Decreased level of serotonin

43%

20/47

Enlargement of the ventricles

9%

4/47

Increased activity of the caudate

40%

19/47

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This patient has obsessive compulsive disorder (OCD) as demonstrated by his recurring intrusive thoughts (e.g., family members will die) and repetitive actions (e.g., dividing his food into multiples of 5). OCD is thought to be associated with dysfunction and increased activity of the caudate nucleus.

OCD is characterized by obsessions (e.g., recurrent intrusive thoughts, images, or urges) and compulsions (e.g., repetitive mental or behavioral acts). By performing such compulsions, the individual often feels a sense of “completeness." The disease typically presents during childhood or adolescence and persists throughout life. The disease is multifactorial in pathogenesis, with contributions from both genetic and environmental factors. Patient presentation varies in frequency and severity and the specific obsessions and compulsions also differ among individuals. Some common symptoms/compulsions include cleaning, symmetry, harm, or forbidden/taboo thoughts. Treatment involves cognitive behavioral therapy in conjunction with medications such as selective serotonin reuptake inhibitors (SSRIs) or clomipramine.

Incorrect Answers:
Answer 1: Atrophy of the frontotemporal lobes may be seen in Pick disease or frontotemporal dementia. Patients often present with early changes in personality and behavior.

Answer 2: Atrophy of the hippocampus may be seen in Alzheimer disease, which is the most common cause of dementia in the elderly. Patients often have widespread cortical atrophy, especially at the hippocampus.

Answer 3: Decreased level of serotonin is one of the postulated pathogenesis of depression. Depression is characterized by at least 5 of the 9 diagnostic criteria (sleep disturbance, loss of interest, guilt, low energy, difficulty concentrating, appetite/weight loss, psychomotor retardation, and suicidal ideations) lasting more than 2 weeks.

Answer 4: Enlargement of the ventricles can be seen in patients with schizophrenia, which is a chronic mental disorder characterized by delusions and hallucinations. This patient understands that his actions are “unreasonable” and is not experiencing hallucinations or delusions.

Bullet Summary:
Obsessive-compulsive disorder is associated with increased activity at the caudate nucleus.

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